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LINE Today special report: Great Tree Pharmacy and NTU research team develop golden ratio synbiotics to inspire new thinking on metabolism

As modern people's health awareness increases, the relationship between diet and intestinal health has attracted much attention. Da Shu Pharmacy has partnered with Leeuwenhoek, a startup spin-off from National Taiwan University, to jointly promote research and knowledge popularization related to intestinal health. It hopes to provide the public with more academic information through scientific research and professional knowledge, and explore nutritional intake recommendations that meet health needs.

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Professor Cheng-Chih Hsu of the Department of Chemistry at National Taiwan University and Dr. Wei-Kai Wu of National Taiwan University Hospital collaborated in a study to explore the relationship between a specific formula of synbiotics and the regulation of energy metabolism.

Research by Professor Xu Chengzhi's team from the Department of Chemistry at National Taiwan University shows that intestinal flora is closely related to the secretion mechanism of intestinal secretin GLP-1 (glucagon-like peptide-1). GLP-1 is a hormone related to the human intestine, and the academic community has long been concerned about its relationship with human metabolism. In recent years, the development of GLP-1 receptor agonists has attracted much attention from the global pharmaceutical community. Since the approval of Tirzepatide in the United States in May 2022, the drug has been approved in the European Union, Canada, and Australia for specific indications. In addition, GLP-1 related drugs such as Semaglutide have also been approved in many places around the world, demonstrating its importance in the field of metabolic research.

In addition to drug research, Professor Xu's team also approached the issue from the perspective of intestinal flora. Through long-term research, they found that polyphenols can promote the growth of Bifidobacterium longum in the intestine. This strain can produce the metabolite MTA (5-methylthioadenosine), which further regulates liver metabolic genes, providing more scientific basis for academic research on the relationship between intestinal microorganisms and human metabolism. In terms of further application, Professor Xu's team proposed a combination model with "probiotics + polyphenol prebiotics + postbiotics" as the core as one of the important directions of intestinal health-related research, and continued to explore the interaction between nutrients and the intestinal environment, deepen academic and applied research, and provide more professional references. Through the collaboration with Dashu Pharmacy, both parties hope to further promote scientific research on intestinal health and enhance the public's understanding of the relationship between intestinal microorganisms and human health.

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Leeuwenhoek is based on scientific research, exploring the relationship between intestinal flora and metabolic regulation through research and experiments, and continues to deepen applied research.

Professor Xu said that maintaining healthy living habits is still the basis of health management. He suggested that people should establish a long-term, stable and healthy lifestyle through a diverse diet, regular work and rest schedule, and proper exercise, combined with nutritional intake recommendations supported by scientific research, so that health management can become a part of daily life.

Original URL:https://today.line.me/tw/v2/article/5y7WxvM