Akkermansia muciniphila

Akkermansia
muciniphila

Leading a New Era of Gut Health

Akkermansia muciniphila is the pioneer of next-generation probiotics
It has been widely recognized to play a role in maintaining the integrity of the intestinal barrier
Key role in regulating host metabolism and promoting immune balance
Akkermansia muciniphila is a pioneer of next-generation probiotics and has been widely recognized for its key role in maintaining intestinal barrier integrity, regulating host metabolism and promoting immune balance.
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Akkermansia muciniphila
Akkermansia muciniphila is a Gram-negative, anaerobic bacterium that inhabits the mucus layer of the human intestine.
This strain was first isolated in 2004 and belongs to the phylum Verrucomicrobia.
It plays a key role in regulating host metabolism and maintaining intestinal mucosal stability.
Akkermansia muciniphila is a Gram-negative, anaerobic bacterium that inhabits the mucus layer of the human intestine. This strain was first isolated in 2004 and belongs to the phylum Verrucomicrobia. It plays a key role in regulating host metabolism and maintaining intestinal mucosal stability.

Health Benefits

Stimulates GLP-1 Secretion

Promotes satiety and improves insulin sensitivity.

Enhances Gut Barrier Integrity

Upregulates tight junction proteins and mucus layer regeneration.

Modulates Inflammation

Reduces systemic and local gut inflammation.

Improves Lipid and Glucose Metabolism

Shown to reduce liver fat accumulation and blood glucose in preclinical and clinical studies.

Research Insights

Retains biological activity after pasteurization

Pasteurized Akkermansia strains have been shown to improve insulin sensitivity. (Depommier et al., Nat Med, 2019)

Demonstrates a Significant Inverse Association With Obesity Risk

The Akkermansia content in feces was significantly negatively correlated with obesity and type 2 diabetes. (Dao et al., 2016)

Helps promote liver lipid metabolism and improve metabolic steatohepatitis (MAFLD)

Oral administration of Akkermansia reduces liver fat accumulation and inflammation in a mouse model of nonalcoholic fatty liver disease (NASH). (Everard et al., 2013)

Has the potential to improve the success rate of cancer immunotherapy

This bacterium is a microbial biomarker for tumor immunotherapy response and is positively correlated with the treatment response of cancer patients. (Routy et al., 2018)

The World’s Largest Akkermansia muciniphila Bioresource: Driving Probiotic Discovery

Akkermansia muciniphila
The world's largest bacterial strain resource library

Initiating a Breakthrough in Probiotic Innovation

1 Ngp Rd

Leeuwenhoek collaborated with the National Taiwan University Hospital to isolate Akkermansia muciniphila from the intestines of healthy Taiwanese people and established a local bacterial strain library, which has now become the world's largest bacterial strain database for this bacterium.

From Genes to Functions, Fully Understand the Potential of Strains

From genes to functions
Fully understand the potential of strains

Whole Genome Sequencing

In-depth comparison of genetic differences between strains, understanding of the molecular mechanisms behind functional performance, and providing a basic basis for the development of probiotic functions.
2 Genome Comparison

Metabolome Analysis

Analyzing the metabolic pathway and metabolite composition of the strain is the key to exploring the efficacy of the strain.
3 Metabolic Pathways

MALDI-TOF Mass Spectrometry

Rapid strain identification is accomplished through high-throughput mass spectrometry technology.
Effectively improve the efficiency of strain screening,
Accelerate the development of functional strains for specific health goals.

Through high-throughput mass spectrometry technology, strain identification can be quickly completed, effectively improving strain screening efficiency and accelerating the development of functional strains oriented to specific health goals.

MALDI-TOF: Matrix-Assisted Laser Desorption/Ionization
Time of Flight Mass Spectrometry
Matrix-assisted laser desorption ionization time-of-flight mass spectrometry

4 Maldi Tof Spectrometry

Scaling Up Precision Fermentation

Leeuwenhoek Systematic Precision Fermentation Process

5 Scale Up
Starting with strain screening and culture medium optimization, a series of optimization tests are first conducted on the culture medium to facilitate the effective proliferation and amplification of the strain. During the anaerobic fermentation stage, we continuously correct and optimize the fermentation conditions and strategies through time-series sampling, testing and observation. This process can effectively improve the stability and functionality of next-generation probiotics during mass production, providing a solid foundation for the clinical application and industrialization of the product.

Applications & Product Development

Forms Available

  • Live strains (strict anaerobic conditions required)
  • Pasteurized strains (heat-treated, safe, stable)
  • Cell-free extracts and postbiotics

Potential Applications

  • Functional food and beverages
  • Dietary supplements for metabolic health
  • Gut barrier support and immune modulation
  • Adjunct therapies for MAFLD, obesity, and diabetes
Lwhk Akkermansia Muciniphila 2

FAQs

Its functional effects extend beyond traditional probiotics, influencing host metabolism, immune responses, and gut barrier health.
Yes. Pasteurized strains have undergone clinical evaluation and are considered safe and well-tolerated.
Absolutely. Akkermansia works synergistically with dietary fibers, polyphenols, and other beneficial bacteria.