{"id":1589,"date":"2025-04-22T11:44:27","date_gmt":"2025-04-22T03:44:27","guid":{"rendered":"https:\/\/lwhklab.com.tw\/?page_id=1589"},"modified":"2025-05-02T14:56:01","modified_gmt":"2025-05-02T06:56:01","slug":"akkermansia","status":"publish","type":"page","link":"https:\/\/lwhklab.com.tw\/en\/akkermansia\/","title":{"rendered":"Next-generation probiotic Akkermansia muciniphila"},"content":{"rendered":"
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Akkermansia muciniphila<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Akkermansia
muciniphila<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Leading a New Era of Gut Health <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Akkermansia muciniphila is the pioneer of next-generation probiotics
\nIt has been widely recognized to play a role in maintaining the integrity of the intestinal barrier
\nKey role in regulating host metabolism and promoting immune balance<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Akkermansia muciniphila is a pioneer of next-generation probiotics and has been widely recognized for its key role in maintaining intestinal barrier integrity, regulating host metabolism and promoting immune balance.<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Akkermansia muciniphila<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Akkermansia muciniphila is a Gram-negative, anaerobic bacterium that inhabits the mucus layer of the human intestine.
This strain was first isolated in 2004 and belongs to the phylum Verrucomicrobia.
It plays a key role in regulating host metabolism and maintaining intestinal mucosal stability.<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Akkermansia muciniphila is a Gram-negative, anaerobic bacterium that inhabits the mucus layer of the human intestine. This strain was first isolated in 2004 and belongs to the phylum Verrucomicrobia. It plays a key role in regulating host metabolism and maintaining intestinal mucosal stability.<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Health Benefits<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Stimulates GLP-1 Secretion<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tPromotes satiety and improves insulin sensitivity.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Enhances Gut Barrier Integrity<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Upregulates tight junction proteins and mucus layer regeneration.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Modulates Inflammation<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Reduces systemic and local gut inflammation.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Improves Lipid and Glucose Metabolism<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Shown to reduce liver fat accumulation and blood glucose in preclinical and clinical studies.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Research Insights<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Retains biological activity after pasteurization<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Pasteurized Akkermansia strains have been shown to improve insulin sensitivity. (Depommier et al., Nat Med, 2019)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Demonstrates a Significant Inverse Association With Obesity Risk<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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The Akkermansia content in feces was significantly negatively correlated with obesity and type 2 diabetes. (Dao et al., 2016)<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Helps promote liver lipid metabolism and improve metabolic steatohepatitis (MAFLD)<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Oral administration of Akkermansia reduces liver fat accumulation and inflammation in a mouse model of nonalcoholic fatty liver disease (NASH). (Everard et al., 2013)<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Has the potential to improve the success rate of cancer immunotherapy<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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This bacterium is a microbial biomarker for tumor immunotherapy response and is positively correlated with the treatment response of cancer patients. (Routy et al., 2018)<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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The World\u2019s Largest Akkermansia muciniphila Bioresource: Driving Probiotic Discovery<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Akkermansia muciniphila
The world's largest bacterial strain resource library<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Initiating a Breakthrough in Probiotic Innovation<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Leeuwenhoek collaborated with the National Taiwan University Hospital to isolate Akkermansia muciniphila from the intestines of healthy Taiwanese people and established a local bacterial strain library, which has now become the world's largest bacterial strain database for this bacterium.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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From Genes to Functions, Fully Understand the Potential of Strains<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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From genes to functions
Fully understand the potential of strains<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Whole Genome Sequencing<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tIn-depth comparison of genetic differences between strains, understanding of the molecular mechanisms behind functional performance, and providing a basic basis for the development of probiotic functions.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Metabolome Analysis<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tAnalyzing the metabolic pathway and metabolite composition of the strain is the key to exploring the efficacy of the strain.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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MALDI-TOF Mass Spectrometry<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Rapid strain identification is accomplished through high-throughput mass spectrometry technology.
\nEffectively improve the efficiency of strain screening,
\nAccelerate the development of functional strains for specific health goals.<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Through high-throughput mass spectrometry technology, strain identification can be quickly completed, effectively improving strain screening efficiency and accelerating the development of functional strains oriented to specific health goals.<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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MALDI-TOF: Matrix-Assisted Laser Desorption\/Ionization
Time of Flight Mass Spectrometry
Matrix-assisted laser desorption ionization time-of-flight mass spectrometry<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Scaling Up Precision Fermentation<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Leeuwenhoek Systematic Precision Fermentation Process<\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t\t\t\t\tStarting with strain screening and culture medium optimization, a series of optimization tests are first conducted on the culture medium to facilitate the effective proliferation and amplification of the strain. During the anaerobic fermentation stage, we continuously correct and optimize the fermentation conditions and strategies through time-series sampling, testing and observation. This process can effectively improve the stability and functionality of next-generation probiotics during mass production, providing a solid foundation for the clinical application and industrialization of the product.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Applications & Product Development<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Forms Available<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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  • Live strains (strict anaerobic conditions required)<\/li>
  • Pasteurized strains (heat-treated, safe, stable)<\/li>
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    Potential Applications<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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    • Functional food and beverages<\/li>
    • Dietary supplements for metabolic health<\/li>
    • Gut barrier support and immune modulation<\/li>
    • Adjunct therapies for MAFLD, obesity, and diabetes<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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      FAQs<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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      Q1: Why is Akkermansia called the next generation probiotic? <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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      \n\t\t\t\t\t\t\t\t\tIts functional effects extend beyond traditional probiotics, influencing host metabolism, immune responses, and gut barrier health.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t
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      Q2: Is Akkermansia muciniphila safe for consumption? <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
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      \n\t\t\t\t\t\t\t\t\tYes. Pasteurized strains have undergone clinical evaluation and are considered safe and well-tolerated.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t
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      Q3: Can it be used together with other probiotics or prebiotics? <\/div><\/span>\n\t\t\t\t\t\t\t\n\t\t\t<\/path><\/svg><\/span>\n\t\t\t<\/path><\/svg><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t
      \n\t\t\t\t
      \n\t\t\t\t
      \n\t\t\t\t\t\t\t\t\tAbsolutely. Akkermansia works synergistically with dietary fibers, polyphenols, and other beneficial bacteria.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

      Akkermansia muciniphila Akkermansiamuciniphila \u958b\u555f\u8178\u9053\u5065\u5eb7\u65b0\u6642 […]<\/p>\n","protected":false},"author":3,"featured_media":1703,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1589","page","type-page","status-publish","has-post-thumbnail","hentry"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/lwhklab.com.tw\/en\/wp-json\/wp\/v2\/pages\/1589","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lwhklab.com.tw\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/lwhklab.com.tw\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/lwhklab.com.tw\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/lwhklab.com.tw\/en\/wp-json\/wp\/v2\/comments?post=1589"}],"version-history":[{"count":0,"href":"https:\/\/lwhklab.com.tw\/en\/wp-json\/wp\/v2\/pages\/1589\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/lwhklab.com.tw\/en\/wp-json\/wp\/v2\/media\/1703"}],"wp:attachment":[{"href":"https:\/\/lwhklab.com.tw\/en\/wp-json\/wp\/v2\/media?parent=1589"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}